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Melanotan II – Research Peptide

A cyclic, non-selective melanocortin agonist that made the melanocortin system experimentally tractable.

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* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional.

What Melanotan II is A cyclic lactam analogue of alpha-melanocyte-stimulating hormone. Cyclisation confers far greater metabolic stability and potency than the linear native hormone, which is why it became a standard tool compound for probing melanocortin receptors. Mechanism Non-selective agonist across melanocortin receptor subtypes including MC1R, MC3R and MC4R. MC1R activation on melanocytes drives melanogenesis; MC3R and MC4R sit in central pathways, which is why the compound appears in both pigmentation and CNS literature. Where it appears in research Melanocortin receptor subtype pharmacology Melanogenesis and tyrosinase activity assays MC4R signalling studies Structure-activity work on cyclic peptides History Designed at the University of Arizona in the 1980s by Victor Hruby and Mac Hadley, whose group systematically re-engineered alpha-MSH for stability. That programme also produced the fragment later developed as bremelanotide.

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