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CJC-1295 – Research Peptide

A protease-resistant analogue of the shortest fully active fragment of growth-hormone-releasing hormone.

Price range: $50.00 through $110.00

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* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional.

What CJC-1295 is The first 29 residues of GHRH retain full activity at the receptor. This analogue carries four substitutions that resist enzymatic breakdown, most importantly D-Ala at position 2, which blocks cleavage by dipeptidyl peptidase-IV. Supplied without the drug affinity complex, giving a short pulse rather than sustained exposure. Mechanism Agonist at the GHRH receptor on pituitary somatotrophs. Receptor binding raises intracellular cAMP and triggers release of stored growth hormone in a pulse that resembles endogenous secretion patterns. Where it appears in research GHRH receptor binding and signalling Pulsatile versus continuous secretion models DPP-IV resistance and peptide half-life Somatotroph culture work History Grew out of work on GRF (1-29), standardised as sermorelin. The tetrasubstituted analogue was developed by ConjuChem in the early 2000s alongside the drug-affinity-complex variant, which extends half-life by binding serum albumin.

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